Longevity Stack

The Longevity Stack addresses aging biology at its two most mechanistically validated intervention points. NAD+ — the essential dinucleotide coenzyme consumed by sirtuins, PARPs, and CD38 — declines progressively with age, impairing mitochondrial electron transport efficiency, DNA repair capacity, and epigenetic regulation through sirtuin-mediated histone deacetylation. Direct parenteral NAD+ repletion bypasses the rate-limiting enzymatic bottlenecks that constrain oral precursor strategies, restoring substrate availability for these critical cellular maintenance enzymes.

Epithalon operates through an orthogonal mechanism: activation of telomerase reverse transcriptase (hTERT), the catalytic enzyme responsible for maintaining telomere length at chromosome termini. Telomere attrition is a hallmark of replicative senescence — as telomeres shorten below critical thresholds, cells enter irreversible growth arrest, accumulating as senescent cells that drive tissue dysfunction and chronic inflammation. By supporting telomere maintenance alongside mitochondrial bioenergetics, this stack engages both the energy production and genomic stability dimensions of cellular aging.

ROEHN supplies both components at 99% HPLC-verified purity, supporting research protocols in gerontology, biomarker-driven aging interventions, and translational longevity science.